FIELD: medicine.
SUBSTANCE: method for obtaining a stabilized suspension of red blood cells encapsulating an active ingredient from resealed red blood cells incorporating the active ingredient includes the incubation of resealed red blood cells in an incubation solution at osmolality of at least 280 m Osmole/kg for 30 minutes or longer, the incubation solution does not contain agents that induce denaturation of the red blood cell membrane, and the liquid medium is then removed from the incubated suspension and the obtained red blood cells are suspended in a solution allowing the injection of this suspension to a patient, wherein said incubation solution does not contain bridging or cross-linking agents.
EFFECT: invention relates to a method for stabilizing red blood cell suspensions comprising an active ingredient.
20 cl, 1 dwg, 6 tbl, 4 ex
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