FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, namely to oncology, and can be used to reduce methionine blood flow in cancer treatment, wherein tumor cells are auxotrophic by methionine. Methods according to the invention include administering an effective amount of a composition containing a pyridine oxaphosphate (PLP) encapsulated in erythrocyte enzyme methioninase and administering an effective amount of the non-phosphate form of vitamin B6.
EFFECT: use of inventions enables stable reduction of the methionine level by preserving the activity of the encapsulated enzyme and providing it with an available PLP co-factor.
15 cl, 7 tbl, 8 dwg, 10 ex
| Title |
Year |
Author |
Number |
| PHARMACEUTICAL COMPOSITION COMPRISING ERYTHROCYTES CONTAINING ENZYME DEPENDENT ON PYRIDOXALPHOSPHATE AND COFACTOR THEREOF |
2015 |
- Godfrin, Yann
- Bourgeaux, Vanessa
- Gay, Fabien
- Cortese, Thomas
|
RU2744659C2 |
| METHOD OF TREATING CANCER IN A MAMMAL, INCLUDING A HUMAN, USING METHIONINE AND ASPARAGINE DEPLETION |
2017 |
- Agera Karin
- Berle Villi
- Ge Faben
- Godfren Yan
|
RU2733389C2 |
| METHOD OF PRODUCING A METHIONINE-GAMMA-LYASE ENZYME, AN ANTITUMOR DRUG FDF MGL BASED ON SAID ENZYME AND USE OF SAID AGENT FOR TUMOR GROWTH INHIBITION (VERSIONS) |
2018 |
- Manukhov Ilya Vladimirovich
- Bazhenov Sergej Vladimirovich
- Gnuchikh Evgenij Yurevich
- Pokrovskij Vadim Sergeevich
- Davydov Denis Zhanovich
- Kotova Vera Yurevna
- Bulushova Natalya Vladimirovna
- Zavilgelskij Gennadij Borisovich
|
RU2733440C2 |
| ARGININE DEIMINASE ENCAPSULATED IN ERYTHROCYTES, AND THEIR USE IN TREATMENT OF CANCER AND ARGINASE-1 DEFICIENCY |
2018 |
- Dufour, Emmanuelle
- Blanc, Manuel
- Meyzaud, Aurelien
|
RU2773220C2 |
| METHOD FOR STABILIZING SUSPENSIONS OF RED BLOOD CELLS ENCAPSULATING ACTIVE INGREDIENT AND SUSPENSIONS OBTAINED |
2014 |
- Godfren Yann
- Borzho Vanessa
- Belli Zherom
|
RU2668688C2 |
| CHIMERIC ENZYME MGL-S3 - METHIONINE-GAMMA-LYASE FUSED WITH S3 DOMAIN OF VGF PROTEIN FROM VACCINIA VIRUS, METHOD FOR PRODUCING MGL-S3 AND ANTICANCER PREPARATION BASED ON THIS ENZYME |
2022 |
- Bondarev Nikolai Antonovich
- Bazhenov Sergei Vladimirovich
- Baranova Anna Viacheslavovna
- Pokrovskii Vadim Sergeevich
- Okhrimenko Ivan Stanislavovich
- Manukhov Ilia Vladimirovich
|
RU2816486C2 |
| CHIMERIC ENZYME BASED ON L-METHIONINE-GAMMA-LYASE FUSED WITH VHH ANTIBODY M456, AND DNA FRAGMENT CODING SAID ENZYME |
2022 |
- Bondarev Nikolaj Antonovich
- Manukhov Ilya Vladimirovich
- Buben Mariya Mikhajlovna
- Bazhenov Sergej Vladimirovich
|
RU2813802C1 |
| METHOD FOR INCLUDING BIOLOGICALLY ACTIVE COMPONENTS IN ERYTHROCYTES BY METHOD OF FLOW HYPOOSMOTIC DIALYSIS |
2021 |
- Ataullakhanov Fazoil Inoyatovich
- Zejnalov Azer Mamedovich
- Sinauridze Elena Ivanovna
- Koleva Larisa
|
RU2791817C1 |
| COMPOSITION FOR INDUCTION OF SPECIFIC IMMUNOLOGICAL TOLERANCE |
2010 |
|
RU2782223C2 |
| METHOD FOR PRODUCING METHIONINASE |
0 |
- Berezov Temirbolat Tembolatovich
- Soda Kenii
- Esaki Nobujoshi
- Shugie Kunio
|
SU994554A1 |
