MEANS INCLUDING PERFLUORIDECARBON EMULSION (VARIANTS), ITS USE AND METHOD OF CREATING REVERSIBLE PHARMACOLOGICALLY INDUCED HYPOMETABOLISM AND HYPOTHERMIA Russian patent published in 2018 - IPC A61K31/138 A61K31/475 A61K31/513 A61K31/55 A61K31/5415 A61K31/4045 A61K33/06 A61K47/04 A61K47/00 A61K9/08 A61P43/00 

Abstract RU 2669398 C1

FIELD: pharmaceuticals.

SUBSTANCE: claimed group of inventions relates to pharmaceutical composition intended to provide an agent for induced hypometabolism and hypothermia in mammals. Pharmaceutical composition includes a beta-blocker propranolol, sympatholitic reserpine, an antianginal drug ivabradine, an antihistamine drug diphenhydramine, serotonin hydrochloride, neuroleptic agent with hypothermic effect of pericyazine, antithyroid agent propicil, magnesium sulfate and pharmaceutically acceptable solvent, in the amounts indicated in the claims. Agent further comprises a carrier, which is a perfluorocarbon emulsion. Ratio of the volume of said pharmaceutical composition and the volume of said carrier is from 1:2 to 1:3. Medicament may further comprise a perfluorocarbon emulsion saturated with an inert gas, preferably xenon.

EFFECT: invention provides use of a new agent in emergency medicine.

9 cl, 2 dwg, 2 ex

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RU 2 669 398 C1

Authors

Biryukov Sergej Vladimirovich

Zakharova Nadezhda Mikhajlovna

Komelina Natalya Pavlovna

Kukushkin Nikolaj Ilich

Semenov Vitalij Semenovich

Semenov Ivan Vitalevich

Sklifas Alla Nikolaevna

Fadeeva Irina Sergeevna

Khrenov Maksim Olegovich

Dates

2018-10-11Published

2017-08-11Filed