FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology. CAR expression vector comprising a nucleic acid encoding a chimeric antigenic receptor (CAR) and a nucleic acid encoding an immunomodulatory factor of T cell are described, wherein the nucleic acid encoding the immunomodulatory factor of the T cell is a nucleic acid encoding interleukin-7 and a nucleic acid encoding CCL19. Also described is a CAR-expressing T cell obtained by transferring the next indicated vector or CAR expression vector comprising a nucleic acid encoding CAR, and a nucleic acid encoding interleukin-7, as well as a CAR expression vector containing a nucleic acid encoding CAR, and a nucleic acid encoding CCL19.
EFFECT: invention has an expressed immunity-enhancing effect and anti-cancer activity.
11 cl, 34 dwg, 13 ex
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