CAR EXPRESSION VECTOR AND CAR-EXPRESSING T CELLS Russian patent published in 2018 - IPC C12N15/00 A61K35/26 A61K35/76 A61K35/00 C12N5/10 C12N15/09 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology. CAR expression vector comprising a nucleic acid encoding a chimeric antigenic receptor (CAR) and a nucleic acid encoding an immunomodulatory factor of T cell are described, wherein the nucleic acid encoding the immunomodulatory factor of the T cell is a nucleic acid encoding interleukin-7 and a nucleic acid encoding CCL19. Also described is a CAR-expressing T cell obtained by transferring the next indicated vector or CAR expression vector comprising a nucleic acid encoding CAR, and a nucleic acid encoding interleukin-7, as well as a CAR expression vector containing a nucleic acid encoding CAR, and a nucleic acid encoding CCL19.

EFFECT: invention has an expressed immunity-enhancing effect and anti-cancer activity.

11 cl, 34 dwg, 13 ex