FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a cytotoxic cell, which is macrophage, that contains CAR and adenoviral component Ad5f35, as well as to a composition containing it. A method for preparing the specified cytotoxic cell is also disclosed, providing introduction of CAR to macrophage using an adenoviral vector Ad5f35.
EFFECT: invention is effective for the treatment of tumor or cancer, as well as for the stimulation of an immune response to the target tumor cell or tumor tissue in a subject.
22 cl, 28 dwg
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