FIELD: biotechnology.
SUBSTANCE: invention relates to a chimeric antigen receptor (CAR) polypeptide specifically binding a tumour-associated antigen (TAA), where said CAR includes a TAA-binding domain, a transmembrane domain, an intracellular signalling domain, and a costimulatory signalling region, in which the costimulatory signalling region includes a mutated form of the CD28 cytoplasmic domain. Also disclosed is an immune effector cell comprising a nucleic acid molecule encoding the above CAR polypeptide.
EFFECT: providing anti-tumour immunity in a mammalian subject with a TAA-expressing cancer.
10 cl, 13 dwg, 2 tbl, 2 ex
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