NOVEL COMPLEX OF AGOMELATINE AND SULFONIC ACID, SYNTHESIS METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Russian patent published in 2018 - IPC C07C231/12 C07C233/18 C07C303/22 C07C309/29 C07C309/35 A61K31/165 A61K31/185 A61P25/24 

Abstract RU 2673080 C2

FIELD: chemistry.

SUBSTANCE: invention relates to agomelatine and sulfonic acid complexes of formula (I), where x is 0 or 1 and RSO3H is 1,5-naphthalenedisulfonic acid or benzenesulfonic acid, which have good solubility and stability and can be used to treat disorders of the melatonergic system. .

EFFECT: invention also relates to methods for producing said complexes and a pharmaceutical composition containing them.

14 cl, 6 dwg, 5 tbl, 5 ex

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RU 2 673 080 C2

Authors

Shan Khanbin

Shen Yusyuj

Luo In

Letelle Filipp

Linch Majkl

Dates

2018-11-22Published

2014-07-28Filed