CRYSTALLINE FORM OF 6-[(4R)-4-METHYL-1,1-DIOXIDO-1,2,6-THIADIAZINAN-2-YL]ISOQUINOLINE-1-CARBONITRILE Russian patent published in 2019 - IPC C07D417/04 A61K31/549 A61P19/00 A61P21/00 

Abstract RU 2698194 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a crystalline form of 6-[(4R)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile, which demonstrates an X-ray powder diffraction pattern having characteristic peaks , expressed in degrees 2-theta (±0.2° 2-theta) at 7.8, 10.9 and 15.2. Invention also relates to its production method.

EFFECT: obtaining a novel crystalline form of 6-[(4R)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile, having thermal stability and non-hygroscopicity.

8 cl, 4 dwg, 3 tbl, 14 ex

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RU 2 698 194 C2

Authors

Chekler, Eugene Lvovich Piatnitski

Dorow, Roberta Louise

Sperry, Jeffrey Braden

Dates

2019-08-23Published

2015-05-01Filed