METHOD OF PREVENTION OF INTRAPERITONEAL POSTOPERATIVE ADHESIONS Russian patent published in 2018 - IPC A61B17/00 A61M31/00 A61K31/198 A61K31/167 A61P41/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to surgery, and can be used to prevent the formation of intra-abdominal adhesions after undergoing operations on the abdominal organs. For this purpose perform a combined drug therapy. Within 2 days before the operation, Tivortin is administered every 12 hours, 50 ml intravenously at a rate of 20 drops per minute. In the intraoperative period, Parecoxib is administered at a dose of 120 mg intraperitoneally by irrigating the surgical field immediately before the completion of the surgical manual. In the early postoperative period: 2 hours after the operation, Parecoxib is administered at a dosage of 60 mg intravenously, followed by a 12-hour administration at a dosage of 30 mg intravenously for 3 days. In the postoperative period for 3 days, Tivortin is administered every 12 hours, 50 ml intravenously at a rate of 20 drops per minute. From the 4^th postoperative day for 10 days, oral administration of Tivortin 1 g 3 times a day is carried out.

EFFECT: method reduces the likelihood of formation of intra-abdominal adhesions and the occurrence of adhesive disease after undergoing simultaneous operations, in particular, for cholelithiasis and ventral hernias, due to the pronounced anti-inflammatory effect and reduction of the process of fibrous-connective tissue changes caused by the simultaneous blocking of the synthesis of cyclooxygenase-2 and cytoprotection, membrane stabilization, which are achieved due to the introduction of these drugs at certain stages of treatment.

1 cl, 2 ex