HYDROXYPURINE COMPOUNDS AND WAYS OF THEIR USE Russian patent published in 2018 - IPC C07D473/04 C07D473/14 A61P29/00 A61P19/02 A61P11/00 A61P25/28 A61P9/10 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a novel compound of formula (I), its (R)-isomer or (S)-isomer, or a pharmaceutically acceptable salt thereof. In the compound of formula (I) Group can be replaced by L₁₁ is absent or means C(R)(R'); each of R and R' is independently selected from H or optionally substituted C₁-C₆ alkyl or C₁-C₆ heteroalkyl, containing 1 to 2 oxygen atoms as a heteroatom, wherein the substituents in R and R' are selected from halogen atoms; wherein R, R' optionally form C₃-C₆ cycloalkyl, 5–6 membered heterocycloalkyl with an oxygen atom as a heteroatom; A is selected from ,

L₁₂ is selected from methylene, R₁ is selected from optionally substituted C₁-C₆ alkyl, wherein the substituents in R₁ are selected from halogen atoms, C₁-C₆ alkyl and C₃-C₆ cycloalkyl.

EFFECT: compounds possess the properties of PDE2 or TNF-α and can find use in the treatment of diseases such as, for example, pulmonary hypertension.

7 cl, 60 ex, 3 tbl