S1P1 AGONIST AND ITS APPLICATION Russian patent published in 2021 - IPC C07D413/04 C07D403/04 C07D409/04 C07D417/04 C07D417/14 C07D471/04 C07D487/04 A61K31/437 A61P37/02

Abstract RU 2754845 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a class of tricyclic compounds and their use as an agonist of the sphingosine 1-phosphate receptor type 1 (S1P1). In particular, the present invention relates to a new compound represented by formula (II), its tautomer and a pharmacologically acceptable salt, wherein the values of X, A, B, D, R₁-R₃ are defined in the claim.

EFFECT: compounds are designed to treat diseases associated with S1P1, such as autoimmune diseases, multiple sclerosis, bronchial asthma, and stroke.

47 cl, 2 tbl, 56 ex

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RU 2 754 845 C2

Authors

Wu, Lingyun

Zhang, Peng

Li, Jian

Chen, Shuhui

Dates

2021-09-08—Published

2017-07-21—Filed