INHIBITOR OF CERTAIN PROTEIN KINASES Russian patent published in 2020 - IPC C07D487/04 C07D471/14 C07D519/00 A61K31/506 A61P29/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a new compound of formula (I) or a pharmaceutically acceptable salt thereof. In formula (I)

Q is 6-member heteroaryl containing one or two heteroatoms selected from N; W is selected from N and CН; Z is selected from N and CR⁶; R¹ is selected from heterocyclyl-C_1-4 alkyl, where heterocyclyl is 6–12-member mono- or bicyclic ring containing one or two nitrogen atoms or one or two nitrogen atoms and one oxygen atom, and alkyl and heterocyclyl are unsubstituted or substituted with at least one substitute, such as one, two, three or four substitutes independently selected from R^X; each R² is hydrogen; each R³ is independently selected from hydrogen and C_1-6 alkyl, where alkyl is unsubstituted or substituted with one, two, three or four substitutes independently selected from R^X; or two R³ together with carbon atoms, to which they are bonded, form 3–7-member cyclic ring not containing additional heteroatoms and optionally substituted with 1, 2 or 3 groups R^X; R⁴ is selected from hydrogen and halogen; each R⁵ is hydrogen; each R⁶ is independently selected from hydrogen and fluorine; each R^X is independently selected from C_1-6 alkyl, 6-member heterocyclyl containing two nitrogen atoms, halogen, -NR^a1R^b1 and -OR^a1, where alkyl and heterocyclyl are unsubstituted or substituted with at least one substitute, such as one, two, three or four substitutes independently selected from R^Y; each R^a1 and each R^b1 are independently selected from hydrogen and C_1-6 alkyl; R^Y is independently selected from C_1-10 alkyl; m is 2 or 3; n is selected from 0, 1 and 2; p is selected from 0, 1, 2 and 3; q is selected from 1, 2 and 3.

EFFECT: compounds have cyclin-dependent kinase 4/6 (CDK4/6) inhibitor properties and can be used for treating CDK4/6 related diseases, for example, for treating proliferative diseases.

23 cl, 6 tbl, 169 ex