METHOD FOR SYNTHESIS OF ALPHA-AMINOALKYLENEPHOSPHONIC ACID Russian patent published in 2018 - IPC C07F9/38 C07F9/572 C07F9/6524 C07F9/6533 A01N57/20 C08F8/40 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for the synthesis of alpha-aminoalkylenephosphonic acid or its ester, used, for example, to treat water, slow down scaling, detergent additives, complexing agents. Method includes the following steps: a) obtaining a reaction mixture by mixing a compound containing one or more P-O-P anhydride moieties, wherein said moieties contain one P atom with oxidation state (+III) and another P atom with oxidation state (+III) or (+V), alpha-aminoalkylenecarboxylic acid and acid catalyst, where said compound containing one or more P-O-P anhydride moieties containing one P atom in oxidation state (+III) and another P atom in oxidation state (+III) or (+V), is selected from the group consisting of: tetraphosphorous hexoxide, P₄O₇, P₄O₈, P₄O₉, tetraphosphorus decaoxide, tetraethyl pyrophosphite, dimethyl phosphite and combinations thereof, and where said alpha-aminoalkylenecarboxylic acid is selected from the group consisting of: nitrile triacetic acid, ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, N-benzyliminodioacetic acid, N-methyliminodiacetic acid, iminodiacetic acid, N,N-bis(carboxymethyl)-1-glutamic acid, trisodium-N,N-bis(carboxymethyl)-alanine, N-cyanomethylalanine, N,N-bis(cyanomethyl)glycine, 4-morpholino acetic acid, pyroglutamic acid, N-acetylglycine, N,N-bis(carboxymethyl)-6-aminocaproic acid, N-phenylglycine, N-tosylglycine, trans-1,2-cyclohexyldiaminotetraacetic acid monohydrate, N-phosphonomethylaminodiacetic acid, iminodiacetic acid grafted onto a resin, such as, for example, acidified Amberlite IRC748i, 1,4,7,10-tetraazadodecane-1,4,7,10-tetraacetic acid, monohydrate of trans-1,2-cyclohexyldiaminotetraacetic monohydrate acid mono N,N'dimethylglycine; b) adding water to the reaction mixture after completing the conversion of alpha-aminoalkylenecarboxylic acid to alpha-aminoalkylenephosphonic acid, and c) isolating from the said reaction mixture the resulting alpha-aminoalkylenephosphonic acid compound or ester thereof.

EFFECT: disclosed method enables to obtain the desired product with high selectivity, purity and yield.

31 cl, 1 tbl, 4 ex