METHOD FOR SYNTHESIS OF N-(PHOSPHONOMETHYL)GLYCINE Russian patent published in 2018 - IPC C07F9/38 A01N57/20 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for the synthesis of N-(phosphonomethyl)glycine and can be used in the chemical industry. Disclosed method for the synthesis of N-(phosphonomethyl)glycine or a salt thereof includes the following steps: a) forming, in the presence of an acid catalyst, a reaction mixture containing 2,5-diketopiperazine, formaldehyde and a compound containing one or more P-O-P anhydride moieties, wherein said moieties contain one P atom in the oxidation state (+III) and another P atom in the oxidation state (+III) or (+V), to form N,N'-bisphosphonomethyl-2,5-diketopiperazine, wherein the compound containing one or more P-O-P anhydride moieties, where said moieties contain one P atom in oxidation state (+III) and another P atom in oxidation state (+III) or (+V), is selected from tetraphosphorus hexoxide, P₄O₇, P₄O₈, P₄O₉, tetraphosphate decaoxide, tetraethyl pyrophosphite, dimethyl phosphite, and combinations thereof; and b) hydrolysing said N,N'-bisphosphonomethyl-2,5-diketopiperazine to obtain N-(phosphonomethyl)glycine or a salt thereof, wherein if the hydrolysis is carried out under basic conditions, the N-(phosphonomethyl)glycine salt contains a carboxylate and/or phosphonate anion of N-(phosphonomethyl)glycine and an alkali metal, alkali-earth metal or ammonium cation; if the hydrolysis is carried out under acidic conditions, the salt of N-(phosphonomethyl)glycine or salt thereof contains the ammonium cation of N-(phosphonomethyl)glycine and the anion, which passes from the acid used for the hydrolysis; and/or the cation of the salt of N-(phosphonomethyl)glycine is selected from the group consisting of ammonium, isopropylammonium, ethanolammonium, dimethylammonium, trimethylsulphonium, alkali or alkali-earth metal.

EFFECT: novel efficient method for obtaining N-(phosphonomethyl)glycine is disclosed.

49 cl, 42 ex