MODEL OF CLOSED BLUNT SEVERE LIVER INJURY WITH COAGULOPATHY IN SMALL LABORATORY ANIMALS Russian patent published in 2018 - IPC G09B23/28 A61K38/39 A61P43/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to experimental surgery. Use the device for the injury of small laboratory animals by the "blow" mechanism, namely the traumatic impact of a cargo weighing 425 g, which falls from a height of 28 cm and transfers its energy to the anterior abdominal wall of a laboratory rat weighing 360–390 g, lying in a supine position with the orientation of the center of the shock pad with a diameter of 3.5 cm 5 mm to the right and above the tip of the xiphoid process. 1 ml of blood is taken from the carotid artery immediately before the injury and 60 minutes after it for 1 minute, which simulates excessive bleeding from the liver vessels immediately after the injury and its amplification during laparotomy, when a revision of the abdominal cavity is performed. Necessity of such sampling is dictated by the faster formation of fibrin in rats and, as a consequence, an earlier stop of bleeding compared with a human, even with massive liver damage. First 20 minutes after the injury simulate the situation of waiting for medical care to the victims, so there is no fluid resuscitation, which corrects hypotension. Prehospital phase is modeled from 20 to 60 minutes, when the patient receives infusion therapy with maintaining systolic blood pressure at the level of 80–90 mm Hg and is delivered to the hospital. By the 60^th minute, a laparotomy is performed, and one or another surgical technique is performed. Study of the hemostasis system showed the presence of coagulopathy after such an injury by 60^th minute.

EFFECT: method allows to create a model of a closed blunt severe liver injury with coagulopathy in small laboratory animals, which is closest to the real situation in life.

1 cl, 1 ex