METHOD OF THE N-ALKYL(PHENYL)-N,N-BIS[4-ALKOXY(PHENOXY-, BENZYLOXY-, PROP-2-YNYLOXY)-2-BUTYNYL]AMINES PREPARATION Russian patent published in 2018 - IPC C07C213/08 C07C217/46 C07C217/52 C07C217/64 

FIELD: chemistry.

SUBSTANCE: compounds of general formula (1) can be used as universal precursors for fine organic synthesis and biologically active compounds. In the general formula (1)

method is that N-alkyl(phenyl)-1,5,3-dioxazepane of general formula R¹N(CH₂OCH₂)₂ (where R¹ = Ph, n-Bu, tert-Bu) is subjected to reaction with the propargyl ester of general formula HC≡CCH₂OR², where R² = tert-Bu, Ph, CH₂C≡CH, Bn, in the presence of a CuCl catalyst at a molar ratio of N-alkyl(phenyl)-1,5,3-dioxazepane : propargyl ether : CuCl = 1:2:(0.03-0.07) under argon atmosphere at a temperature of 80°C and atmospheric pressure under toluene environment for 5-7 hours.

EFFECT: invention relates to a novel process of novel N-alkyl(phenyl)-N,N-bis[4-alkoxy(phenoxy, benzyloxy or prop-2-ynyloxy)-2-butynyl]amines preparation of general formula (1).

1 cl, 1 tbl, 10 ex