METHOD OF PRODUCING 3-ARYL-1,5,3-DIOXAZEPANES Russian patent published in 2014 - IPC C07D273/01 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, particularly a method of producing 3-aryl-1,5,3-dioxazepanes of general formula (1a-i): R=H (a), m-CH₃ (b), p-CH₃ (c), o-OCH₃ (d), m-OCH₃ (e), p-OCH₃ (f), o-NO₂ (g), m-NO₂ (h), p-NO₂ (i), characterised by that N,N-bis(methoxymethyl)-N-arylamine (aryl = phenyl, m- and p-methylphenyl, o-, m- and p-methoxyphenyl, o-, m- and p-nitrophenyl) reacts with 1,2-ethylene glycol in the presence of a Sm(NO₃)₃·6H₂O catalyst, taken in molar ratio N,N-bis(methoxymethyl)-N-arylamine: 1,2-ethylene glycol:Sm(NO₃)₃·6H₂O=10:10:(0.3-0.7), preferably 10:10:0.5 at room temperature (20°C) and atmospheric pressure in chloroform as a solvent for 1-2 hours.

EFFECT: novel method of producing 3-aryl-1,5,3-dioxazepanes of general formula (1a-i), which can be used as antibacterial, antifungal and antiviral agents and also in fine organic synthesis.

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