ALK KINASE INHIBITORS Russian patent published in 2018 - IPC C07D405/14 C07D401/14 A61K31/506 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a new compound of formula (I) or a pharmaceutically acceptable salt thereof. Compounds are protein kinase inhibitors and have antiproliferative activity. Compounds can be used to treat, reduce severity or prevent a condition that responds to the inhibition of anaplastic lymphoma kinase. In the compound of formula (I) (I) each R¹ is independently selected from hydrogen and C_1-10 alkyl, where C_1-10 alkyl is unsubstituted or is substituted by at least one substituent independently selected from R^6a; each R² is independently selected from C_1-10 alkyl and piperidinyl provided that at least one group R² is piperidinyl, where piperidinyl is unsubstituted or substituted by at least one substituent independently selected from R^6a; each R³ is independently selected from hydrogen and C_1-10 alkyl; each R⁴ is independently selected from hydrogen, halogen and C_1-10 alkyl or R³ and R⁴ together with the carbon atoms to which they are attached, form a 5-membered ring containing 2 nitrogen heteroatoms and optionally substituted with 1-2 R^6b groups; each R⁵ is independently selected from -S(O)_rR⁷; each R^6a is independently selected from C_1-10 alkyl, -OR⁸, -S(O)_rR⁷, -(CR⁹R¹⁰)_tOR⁸, -(CR⁹R¹⁰)_tS(O)_rR⁸, -(CR⁹R¹⁰)_tCO₂R⁸, -(CR⁹R¹⁰)_tCONR⁷R⁸, -C(O)R⁷, -C(O)(CR⁹R¹⁰)_tOR⁸, -C(O)(CR⁹R¹⁰)_tNR⁷R⁸, -CO₂R⁸ and -C(O)NR⁷R⁸; each R^b6 is independently selected from C_1-10 alkyl; each R⁷ and each R⁸ are independently selected from hydrogen, C_1-10 alkyl and C_3-10 cycloalkyl or R⁷ and R⁸ together with the atom(s) to which they are attached, form a heterocyclic 5-6-membered ring containing 1 additional heteroatom selected from oxygen and NR¹¹; each R⁹ and each R¹⁰ are independently selected from hydrogen and C_1-10 alkyl; each R¹¹ is independently selected from hydrogen and C_1-10 alkyl; each m is independently selected from 0, 1, and 2; each n is 1; each p is independently selected from 1, 2 and 3; each q is independently selected from 0, 1, 2, and 3; each r is 2; each t is independently selected from 1, 2 and 3.

EFFECT: proposed are ALK kinase inhibitors.

22 cl, 1 dwg, 3 tbl, 58 ex