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(19)

(11)

2 836 176

(13)

(51)

IPC

C07D471/22(2006-01-01)

C07D487/14(2006-01-01)

C07D491/22(2006-01-01)

C07D495/22(2006-01-01)

C07D498/22(2006-01-01)

A61K31/519(2006-01-01)

A61K31/5383(2006-01-01)

A61K31/55(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2022103667, 2020-07-16

(24)

Start date

2020-07-16

(22)

Actual filing date

2020-07-16

(45)

Published

2025-03-11

(72)

Inventor

Wang, ShaomengRej, RohanWang, ChangweiWang, MiLu, JianfengYang, Chao-YieFernandez-Salas, EsterStuckey, Jeanne

(73)

Holder

The Regents Of The University Of Michigan

IMIDAZOPYRIMIDINES AS EED INHIBITORS AND USE THEREOF Russian patent published in 2025 - IPC C07D471/22 C07D487/14 C07D491/22 C07D495/22 C07D498/22 A61K31/519 A61K31/5383 A61K31/55 A61P35/00

Abstract RU 2836176 C2

FIELD: medicine.

SUBSTANCE: invention relates to an imidazopyrimidine compound selected from a group of compounds specified in the claim. Invention also relates to a pharmaceutical composition containing a compound, a method of treating cancer mediated by EED protein activity, use of the compound for producing a drug for treating cancer mediated by EED protein activity, a method for inhibiting EED protein and a kit for treating cancer mediated by EED protein activity.

EFFECT: imidazopyrimidine compounds having EED inhibitory activity for treating EED-mediated diseases.

14 cl, 2 dwg, 7 tbl, 33 ex

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RU 2 836 176 C2

Authors

Wang, Shaomeng

Rej, Rohan

Wang, Changwei

Wang, Mi

Lu, Jianfeng

Yang, Chao-Yie

Fernandez-Salas, Ester

Stuckey, Jeanne

Dates

2025-03-11—Published

2020-07-16—Filed