PEPTIDES Russian patent published in 2018 - IPC C07K14/72 A61K39/00 A61P37/00 A61P5/16 

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, specifically to peptides from the human thyroid stimulating hormone receptor (TSHR), and can be used in medicine to prevent or suppress the activation of the formation of autoimmune antibodies in Graves' disease. On the basis of TSHR peptides are received KKGIYVSIDVTLQQLESHGKK, KKKIYVSIDVTLQQLESHKKK, KKGYVSIDVTLQQLESHSGKK, ISRIYVSIDVTLQQL, SRIYVSIDVTLQQLE, RIYVSIDVTLQQLES, IYVSIDVTLQQLESH, YVSIDVTLQQLESHS, VSIDVTLQQLESHSF, KKGVSIDVTLQQLESHSFGKK, KKGSNLPNISRIYVSIDVGKK, SNLPNISRIYVSIDV, NLPNISRIYVSIDVT, KKGNLPNISRIYVSIDVTGKK, GLKMFPDLTKVYSTD, TGLKMFPDLTKVYST, LKMFPDLTKVYSTDI, KMFPDLTKVYSTDIF, LTLKLYNNGFTSVQG, TLKLYNNGFTSVQGY, KKK TLKLYNNGFTSVQGYKKK as well as other.

EFFECT: invention allows to obtain a peptide based on TSHR, which is capable of binding to a class I or II MHC molecule in vitro and can be presented to T-cells without antigen processing.

15 cl, 20 dwg, 1 tbl, 5 ex