FIELD: biotechnology.
SUBSTANCE: invention relates to a nucleic acid containing exon 2 and exon 3 of theα human leukocyte antigen (HLA) class II gene, functionally related to exon 4 ofα MHC II rodent gene, andα the rodent MHC II gene is aα rat or mouse MHC II gene and/or ii) exon 2 and exon 3 of theβ HLA class II gene is functionally associated with exon 4 and exon 5 ofβ MHC II rodent gene, andβ the rodent MHC II gene isβ MHC II rat or mouse gene, as well as to the cell containing it.
EFFECT: invention is effective for the expression of the humanized MHC II protein.
9 cl, 9 dwg, 4 ex
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