FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to epitope peptides, and can be used in medicine for the treatment of a demyelinating disease, such as multiple sclerosis. Peptide fragments from proteolipid protein (PLP) were obtained: PLP 39-53: LTGTEKLIETYFSKN; PLP 42-56: TEKLIETYFSKNYQD; PLP 43-57: KLIETYFSKNYQDY; PLP 180-194: WTTCQSIAFPSKTSA; PLP 181-195: TTCQSIAFPSKTSAS; PLP 182-196: TCQSIAFPSKTSASI; PLP 183-197: CQSIAFPSKTSASIG; PLP 184-198: QSIAFPSKTSASIGS; PLP 208-222: VLPWNAFPGKVCGSN; PLP 36-61: HEALTGTEKLIETYFSKNYQDYEYLI; PLP 179-206: TWTTCQSIAFPSKTSASIGSLCADARMY and PLP 207-234: GVLPWNAFPGKVCGSNLLSICKTAEFQM.
EFFECT: invention provides a peptide epitope of PLP capable of binding to an MHC molecule in vitro and to be presented to a T cell without antigen processing.
8 cl, 15 dwg, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PEPTIDE | 2014 |
|
RU2675479C2 |
| PEPTIDES | 2014 |
|
RU2676149C2 |
| COMPOSITION | 2015 |
|
RU2773344C2 |
| COMPOSITION | 2015 |
|
RU2728963C2 |
| MULTIVALENT VACCINE AGAINST BREAST CANCER | 2013 |
|
RU2645085C2 |
| MODIFIED EPITOPES FOR AMPLIFYING RESPONSES OF CD4+ T-CELLS | 2013 |
|
RU2724994C2 |
| PEPTIDE CONJUGATED PARTICLES | 2014 |
|
RU2685186C2 |
| METHOD FOR TREATING AUTOIMMUNE DISEASE USING BIOCOMPATIBLE BIOABSORBABLE NANOSPHERE | 2011 |
|
RU2635537C2 |
| DNA COMPOSITION FOR INDUCING IMMUNE RESPONSE ON TUMOUR-ASSOCIATED MACROPHAGUES | 2007 |
|
RU2459631C2 |
| APPLICATION OF INHIBITING TGF-beta1 PEPTIDES FOR PREPARATION OF AGENT MODULATING IMMUNE RESPONSE | 2005 |
|
RU2420307C2 |
