FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to a pharmaceutical dosage form in the form of a soft gelatin capsule, comprising: a shell containing gelatin and a plasticiser; and filler encapsulated in the shell. Filler contains less than 1.0 % by weight of water before encapsulation, and additionally contains at least one pharmaceutically-active active ingredient, one or more polyethylene glycols and hydroxypropyl guar gum. At least one pharmaceutically-active active ingredient is selected from the group consisting of estradiol, its pharmaceutically acceptable salts, esters, hydrates, prodrugs and derivatives.
EFFECT: soft gelatin capsule dosage form of the invention maintains its shell integrity (hardness) and fill viscosity over the time of storage.
18 cl, 9 dwg, 9 tbl
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