FIELD: biotechnology; pharmaceutics.
SUBSTANCE: disclosed are soft gelatine sustained-release capsules containing a filling material and a shell composition, wherein the filling material contains at least one active agent, and the coating composition contains gelatine, dextrose and a pH-dependent polymer containing pectin and gellan gum. Described also are methods of producing such capsules and a method for controlling the pH-dependent dissolution profile of a sustained-release soft gelatine capsule and a method of delivering an active agent to a target site in the gastrointestinal tract by administering a sustained-release soft gelatine capsule to a subject.
EFFECT: group of inventions enables to stabilize and reduce the flow of a pH-dependent polymer, such as pectin, soft gelatine capsules in an acidic medium with dextrose content.
29 cl, 11 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| SUSTAINED RELEASE SOFT GELATINE CAPSULES | 2020 |
|
RU2822392C2 |
| ENTERIC COATED SOFT GELATIN CAPSULES | 2019 |
|
RU2815635C2 |
| SOFT GRANULAR GELATIN CAPSULES WITH PH-INDEPENDENT RELEASE | 2016 |
|
RU2738933C2 |
| NICOTINE COMPOSITION FOR PERORAL APPLICATION, WHICH CONTAINS AMINO-ACID BUFFER | 2008 |
|
RU2465904C2 |
| CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS UNSTABLE IN MEDICINAL ACID MEDIUM | 2006 |
|
RU2440101C2 |
| ENTERIC CAPSULES OF SOFT GELATIN | 2019 |
|
RU2789789C2 |
| GELLAN SEAMLESS, ABLE FOR MECHANICAL DESTRUCTION CAPSULE AND METHOD OF OBTAINING IT | 2006 |
|
RU2428971C2 |
| MICROCAPSULES | 2004 |
|
RU2359662C2 |
| SMOKING DEVICE WITH FRAGILE CAPSULE, FRAGILE CAPSULE AND ITS PRODUCTION METHOD | 2006 |
|
RU2415618C2 |
| PANCREATINE MICROPELLET NUCLEI TO BE ENTERO-SOLUBLE COATED | 2006 |
|
RU2408364C2 |
