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2 591 195

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IPC

C07D471/04(2006-01-01)

A61K31/437(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2013132758/04, 2011-12-13

(24)

Start date

2011-12-13

(22)

Actual filing date

2011-12-13

(45)

Published

2016-07-10

(72)

Inventor

Bojz Mark LourensDelisl Robert KirkKhiken Erik DzhejmsKennedi Ejpril L.Mareska Devid A.Marmseter Fredrik P.Manson Mark K.Nyukhaus BredRast BrajsonRitstsi Dzhejmz P.Rodriges Marta I.Topalov Dzhordzh T.Chzhao Tszyan

(73)

Holder

Errej Biofarma Ink.

SUBSTITUTED N-(1H-INDAZOLE-4-YL) IMIDAZOLE [1,2-A]PYRIDINE-3- CARBOXAMIDE COMPOUNDS AS INHIBITORS OF TYROSINE KINASE TYPE III RECEPTOR Russian patent published in 2016 - IPC C07D471/04 A61K31/437 A61P35/00

Abstract RU 2591195 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I and their pharmaceutically acceptable salts, where R¹, R², R³, R⁴, R⁵ and R⁶ have values specified in patent claim. Compound of formula I are inhibitors of tyrosine kinase of type III, and, in particular, cFMS. They are effective in treating fibrosis, bone diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in mammal.

EFFECT: invention also relates to methods of producing compounds of formula I, pharmaceutical compositions containing them and methods of treating said diseases.

47 cl, 1 tbl, 161 ex

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RU 2 591 195 C2

Authors

Bojz Mark Lourens

Delisl Robert Kirk

Khiken Erik Dzhejms

Kennedi Ejpril L.

Mareska Devid A.

Marmseter Fredrik P.

Manson Mark K.

Nyukhaus Bred

Rast Brajson

Ritstsi Dzhejmz P.

Rodriges Marta I.

Topalov Dzhordzh T.

Chzhao Tszyan

Dates

2016-07-10—Published

2011-12-13—Filed