COMPOSITION, CONTAINING MIXED EXTRACT OF MULBERRY AND PORIA COCOS SKIN, INTENDED FOR PREVENTION, RELIEF AND TREATMENT OF NEURODEGENERATIVE DISORDERS Russian patent published in 2019 - IPC A61K36/605 A61K36/76 A61P25/28 A61P25/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a pharmaceutical composition, namely, a composition for the prevention or treatment of degenerative neurological disease. Pharmaceutical composition for the prevention or treatment of degenerative neurological disease, containing an extract of a mixture containing (i) mulberry and (ii) the skin of Poria cocos as an active substance, wherein the mixture is extracted using water, alcohol or a mixture of water and alcohol, and in a mixture of from 4 to 7 weight parts of mulberry fall on 1 weight part of the skin of Poria cocos, while the pharmaceutical composition is capable to (i) improve spatial memory, (ii) improve cognitive memory, (iii) increase the expression of neural cells (NeuN), (iv) reduce the expression of apoptosis marker (FJB), (v) inhibit formation β-amyloid, (vi) promote the formation of neurotrophic growth factor, (vii) inhibit the activity of acetylcholinesterase (AChE), (viii) inhibit cytotoxicity, (ix) inhibit tau protein phosphorylation or (x) combine any of the above. Composition for the prevention or treatment of degenerative neurological disease. Method for the prevention or treatment of a degenerative neurological disease of a subject in need thereof, consisting in administering to the subject a pharmaceutical composition according to any one of items 1 and 3–12. Use of a pharmaceutical composition for the manufacture of a medicament for the prevention or treatment of a degenerative neurological disease of a subject in need thereof.

EFFECT: compositions described above are effective for the prevention or treatment of degenerative neurological diseases.

22 cl, 2 dwg, 15 tbl, 4 ex