PHARMACEUTICAL COMPOSITION FOR TREATING DEGENERATIVE BRAIN DISEASE COMPRISING GLYCINE TRANSPORTER AS ACTIVE INGREDIENT Russian patent published in 2024 - IPC A61K38/17 A61K48/00 A61P25/28 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and discloses the use of a pharmaceutical composition containing a glycine carrier protein or a nucleic acid molecule coding a protein, as an active ingredient, for preventing or treating cognitive disorders due to degenerative brain disease, where the degenerative brain disease is selected from the group consisting of Alzheimer's disease, Parkinson's disease, Huntington's disease, mild cognitive disorders, cerebral amyloid angiopathy, amyloid stroke, senile dementia and amyotrophic lateral sclerosis; where the glycine carrier protein is a glycine-1 carrier (GlyT1) and where GlyT1 contains an amino acid sequence encoded by a nucleotide sequence which is at least 90% identical to SEQ ID NO: 1 (embodiments).

EFFECT: effective prevention and/or treatment of various degenerative brain diseases associated with beta-amyloid aggregation, tau-protein aggregation and/or tau-protein hyperphosphorylation.

11 cl, 1 tbl, 5 dwg, 4 ex