PHARMACEUTICAL COMPOSITION CONTAINING VERBENOL DERIVATIVE FOR TREATING OR PREVENTING NEURODEGENERATIVE DISEASE Russian patent published in 2017 - IPC A61K31/122 A61K31/05 A61K31/4402 A61P25/00 

FIELD: pharmaceutics.

SUBSTANCE: present group of inventions relates to verbenol derivatives, pharmaceutical composition for preventing or treating degenerative cerebral disease, selected from stroke, paralysis, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis, which contains verbenol derivative as active substance, as well as food additive with effect of protection of neurons, suppression of oxidative stress, suppression of cytokines expression, including verbenol derivative, wherein said verbenol derivative is selected from group, consisting of: (1S,5R)-4-(4-hydroxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one; (1S,5R)-4-(3,4-hydroxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one; (1S,5R)-4-(3,4-dihydroxy-5-methoxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one; (1S,5R)-4-(2-hydroxy-4-methoxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one; (1S,5R)-6,6-dimethyl-4-((E)-2-(pyridin-2-yl)vinyl)-bicyclo[3.1.1]hept-3-en-2-one; and their pharmaceutically acceptable salts.

EFFECT: prevention and treatment of cerebral diseases.

7 cl, 10 dwg, 2 tbl, 2 ex