METHOD OF OBTAINING FURO[3,4-C]PYRIDIN-1(3H)-ONE DERIVATIVES Russian patent published in 2019 - IPC C07D491/48 

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to a method for producing 3-phenylamino-substituted furo[3,4-c]pyridin-1(3H)-ones of the general formula (1), where X=C₂H₅, Y=para-CH₃, X=CH₃, Y=ortho-CH₃; X=C₂H₅, Y=ortho-OH; X=CH₃, Y=ortho-OCH₃, comprising reacting 3-hydroxyfuro[3,4-c]pyridin-1(3H)-one with an aromatic amine in a solvent at room temperature, characterized that as 3-hydroxyfuro[3,4-c]pyridin-1(3H)-one is used 4-halogen-3-hydroxy-6-methyl-7-ethylfuro[3,4-c]pyridin-1(3H)-one or 4-halogen-3-hydroxy-6,7-dimethylfuro[3,4-c]pyridin-1(3H)-one, and as aromatic amine use ortho- or para-toluidine, or 2-aminophenol, or ortho-anisidine, while the interaction is carried out in acetonitrile for 20–30 minutes, then evaporated 2/3 of the volume, the precipitated precipitate is filtered off, washed with propan-2-ol.

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EFFECT: obtaining new derivatives furo [3,4-c]pyridin-1(3H)-ones, which can be used in medicine, as substances with antitumor, antibacterial, including anti-tuberculosis and anti-malarial, activity.

1 cl, 4 ex