METHOD OF PRODUCING FURO[3,4-C]PYRIDINE-1(3H)-ONE DERIVATIVES Russian patent published in 2020 - IPC C07D491/48 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing furo[3,4-c]pyridine-3(1H)-one derivatives of general formula (1), where X=Cl, R¹=R²=CH₃; X=Cl, R¹=R²=C₆H₅; X=Cl, R¹+R²=(CH₂)₄; X=Br, R¹=R²=CH₃, which involves reacting corresponding 5,6-disubstituted 2-halopyridine-3,4-dicarboxylic acids with propionic anhydride while heating for 10-12 hours and reducing intermediate 4-halogenfuro[3,4-c]pyridine-1,3-dione with sodium borohydride for 3-4 hours at room temperature, followed by evaporating the reaction mass on a rotary evaporator under vacuum, diluting the residue with water, neutralization with 10% aqueous HCl solution, extraction with ethyl acetate, purification of ethyl acetate extracts by column chromatography and recrystallisation of product after chromatography from propan-2-ole.

EFFECT: method of producing novel derivatives of compounds of formula (I), which can be used in medicine for treating or preventing autoimmune and inflammatory diseases, neurological and psychiatric disorders.

1 cl, 4 ex