METHOD OF OBTAINING AGENT FOR THE TREATMENT OF SOLID-HOOFED ANIMALS WITH PARASITOSIS Russian patent published in 2019 - IPC A61K31/365 A61K47/10 A61K47/58 A61K47/36 A61P33/10 

FIELD: veterinary medicine.

SUBSTANCE: group of inventions relates to veterinary medicine, in particular, to a method for producing an agent for treating solid-hoofed animals with parasitosis, as well as to the agent for treating solid-hoofed animals and the method of treating solid-hoofed animals with nematodosis and botts of the digestive tract. In the laboratory, the preparation is obtained in stage 3, in the first stage, sugar syrup is prepared in a separate container by heating water to +50 °C, with stirring with the addition of sucrose and sodium alginate, in the second stage, in another container at a temperature of +50 °C prepare a solution of an intermolecular complex of ivermectin based on polymers, PEG-400, propylene glycol, PVP-17, in the third stage, a solution of ivermectin is added to the sugar syrup in 3–4 steps, stirring until a white suspension is obtained, in which thickeners are added in the form of white clay and arabinogalactan, thoroughly mixing to obtain a composition in the form of a stable paste, of a light beige color, in following ratio of components, wt. %: ivermectin – 2.0 %, polyethylene glycol-400 – 7.0 %, polyvinylpyrrolidone-17 – 3.0 %, propylene glycol – 33.0 %, sucrose – 8.0 %, purified water – 12.0 %, sodium alginate – 0.3 %, edible white clay – 14.7 %, arabinogalactan – 20.0 %. Agent for the treatment of solid-hoofed animals with parasitosis is a thick sticky paste of light beige color, containing 2.0 % of ivermectin and 98.0 % of forming components. For ease of use, the paste is packaged in disposable syringes-dispensers with a capacity of 10–20 ml, designed for treatment of animal weighing 500–800 kg. Treatment and prophylaxis of solid-hoofed animals (horses, donkeys, mules) with nematodosis and botts of the digestive tract is carried out by agent obtained by the method described above, where the agent is administered once orally by a syringe dispenser along the toothless edge to the root of the tongue in a therapeutic dose of 0.2 mg/kg based on active substance or 1 ml of paste per 100 kg of animal weight.

EFFECT: group of inventions provides an increase in the antiparasitic efficacy of the agent due to the formation of a soluble intermolecular complex, which delivers the drug to the parasite's organism during feeding, as a result of which the nervous system and the carbohydrate metabolism of the parasite are blocked, which causes the parasite to die.

3 cl, 6 ex, 6 tbl