PHARMACEUTICAL FORMULATIONS OF HIF HYDROXYLASE INHIBITORS Russian patent published in 2019 - IPC A61K9/28 A61K31/472 A61K47/02 A61P7/06 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to the pharmaceutical industry and is a pharmaceutical formulation for treatment, pretreatment or delay in the onset or progression of conditions associated with anemia, ischemia, or hypoxia, containing [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]acetic acid, an adjuvant, a photo stabilizing agent that prevents the passage of light in the wavelength range from 200 nm to 550 nm, the specified photo stabilizing agent contains titanium dioxide and an additional dye. Inventions also include a solid dosage form containing said pharmaceutical formulation, which is a tablet, and also a solid dosage form, containing said pharmaceutical formulation, which is a capsule. Invention presents a method of inhibiting photodegradation of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, which includes the preparation of the [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid formulation with an effective amount of a photo stabilizing agent, which contains titanium dioxide and at least one additional dye, a method of treatment, pretreatment or delay in the onset or progression of a condition mediated at least in part by a hypoxia induced factor (HIF), including the administration to a patient in need of a specified pharmaceutical formulation or said solid dosage forms, as well as a method for treatment, pretreatment, or delay of the onset or progression of anemia, including administering to a patient in need thereof said pharmaceutical formulation or said solid dosage forms.

EFFECT: group of inventions provides increased photostability of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid.

27 cl, 4 dwg, 8 tbl, 3 ex