PHARMACEUTICAL COMBINATION, COMPOSITION AND COMPOUND, CONTAINING A GLUCOKINASE ACTIVATOR AND AN ALPHA-GLUCOSIDASE INHIBITOR, METHODS FOR PRODUCTION AND APPLICATION THEREOF Russian patent published in 2022 - IPC A61K31/4155 A61K31/437 A61K31/497 A61K31/702 A61P3/10 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to the field of pharmaceuticals and can be used for treating diabetes and associated metabolic disorders. Hypoglycemic pharmaceutical combination contains a glucokinase activator constituting the compound HMS5552 and an alpha-glucosidase inhibitor constituting acarbose or a pharmacologically acceptable salt thereof. The mass ratio of the glucokinase activator to the alpha-glucosidase inhibitor is therein from 1600:1 to 1:10, the glucokinase activator is present at a dose from 1 mg to 200 mg, and the alpha-glucosidase inhibitor is present at a dose from 0.1 mg to 100 mg. Also proposed are a pharmaceutical composition containing said hypoglycemic pharmaceutical combination, a fixed dose combined compound, a method for preventing, inhibiting the progression of, delaying, or treating one or multiple metabolic disorders, as well as an application of the pharmaceutical combination or composition in the manufacture of a medicinal product.

EFFECT: combination of said alpha-glucosidase inhibitor and glucokinase activator exhibits a synergistic hypoglycemic effect and demonstrates a reduction in the toxic or side effects.

77 cl, 2 dwg, 5 tbl, 9 ex