METHOD OF FORMING BLOOD VESSEL PHANTOMS FOR ENDOSCOPIC OPTICAL COHERENT ELASTOGRAPHY Russian patent published in 2019 - IPC A61B6/00 G09B23/28 

FIELD: medicine.

SUBSTANCE: invention relates to medical technology, and in particular to methods of forming layered phantoms of blood vessels, and can be used in medicine and veterinary medicine to train personnel in performing diagnostic measurements on endoscopic coherent optical tomographs. Method comprises the manufacture of a casting mold, repeating the contour of the simulated human tissue, filling the casting mold with two-component liquid silicone with a Young's modulus in the range from 2 to 30 kPa, forming in separate casting molds simulators of pathological tissue structures from two-component liquid silicone with a Young's modulus in the range from 30 to 600 kPa, the use of special additives to enhance the contrast in the formation of simulators of pathological tissue structures, addition of separately formed simulators of pathological tissue structures to the filled with two-component liquid silicone casting mold with the contour of the simulated human tissue, coating the outer contour of the manufactured phantom with a protective layer having mechanical properties, like the protective shells of the simulated tissue, moreover, the mechanical properties used in the manufacture of a phantom of a two-component liquid silicone are changed by changing the mass fraction of silicon in it, at the same time, the rate of solidification of a two-component liquid silicone is controlled by a change in temperature, in separate casting molds, hollow structures are formed with three-layer walls, in shape and size corresponding to the blood vessels passing through the simulated human tissue, and having a diameter greater than the diameter of the probe of endoscopic coherent optical tomograph, information about the shape and size of blood vessels in the simulated human tissue is preliminary obtained by angiography, each hollow structure with a three-layer walls has one proximal and at least one distal end, the layers of the walls of the hollow structures sequentially from internal to external are made of two-component liquid silicone, using the same special additives, and the mass fraction of special additives should correspond to the optical properties of the corresponding layer of the simulated hollow structure, while the layers have different thickness after solidification. After solidification of a two-component liquid silicone, hollow structures with three-layer walls are added to a casting mold filled with a two-component liquid silicone with a contour of simulated human tissue together with solidified simulators of pathological tissue structures, for the geometrical arrangement of hollow structures with three-layer walls in a casting mold should correspond to the geometrical arrangement of their associated blood vessels in the simulated human tissue, moreover, information about the geometrical arrangement of these blood vessels in the simulated human tissue is previously obtained by the method of angiography. Proximal and distal ends of the hollow structures with three-layer walls after solidification of two-component liquid silicone in a casting mold, repeating the contour of the simulated human tissue, and coating the outer contour of the solidificated structure with a protective layer is supplied with bifurcated catheters in such a way, so that at the same time there is an opportunity for pumping solutions with optical properties of blood through hollow structures with three-layer walls and introducing an endoscopic optical coherent tomograph into these hollow structures of the probe, moreover, the protective layer also contains special additives to enhance the contrast.

EFFECT: use of the invention allows to increase the reliability of physical modeling of real biological objects or their parts.

1 cl, 1 dwg