COMBINATION OF EGFR INHIBITOR AND MEK INHIBITOR FOR USE IN TREATMENT OF NRAS MUTATED CANCER Russian patent published in 2019 - IPC A61K31/4184 A61K31/506 A61K48/00 A61P35/00

Abstract RU 2683276 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Proposed is an EGFR inhibitor for treatment of non-small cell lung cancer caused by mutated NRAS, where the EGFR inhibitor is administered in combination with a MEK inhibitor and an NRAS mutation is selected from E63K, G12V and G12R, or a gain of copy number of NRAS gene.

EFFECT: invention provides effective treatment for non-small cell lung cancer caused by mutated NRAS using a combination of an EGFR inhibitor with an MEK inhibitor.

6 cl, 10 dwg, 7 tbl, 4 ex

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RU 2 683 276 C2

Authors

Cross Darren Anthony Edward

Eberlein Catherine Anne

Dates

2019-03-27—Published

2015-04-02—Filed