PEPTIDE VACCINE COMPRISING RAS PEPTIDE CONTAINING MUTATIONS, AND CHEMOTHERAPEUTIC AGENT Russian patent published in 2019 - IPC A61K38/00 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to immunology, and can be used for application of peptide corresponding to fragment of RAS protein for cancer treatment. Peptide is suitable for triggering an immune response and corresponds to a RAS protein fragment, but includes one amino acid substitution, the peptide includes a region of at least 8 amino acids which contains position 12 or 13 of the RAS protein, and the amino acid substitution of the peptide is in said position 12 or 13, respectively, and is selected from substitutions G13A, G13C, G13D, G13R, G13S, G13V, G12A, G12C, G12D, G12R, G12S or G12V. Peptide is introduced simultaneously or sequentially with an antimetabolic chemotherapeutic agent. Group of inventions also relates to the use of an ex vivo T cell specific for said peptide, and involves methods of treating cancer.

EFFECT: using the given group of inventions enables to induce a stable immune response in treating cancer by administering a combination of said peptide and an antimetabolistic chemotherapeutic agent.

21 cl, 2 dwg, 4 tbl, 1 ex