METHODS FOR TREATING PANCREATIC CANCER Russian patent published in 2022 - IPC A61K31/18 A61K31/437 A61K31/4427 A61P35/00 C07D487/04 C07D471/04 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to a method of treating pancreatic cancer in a patient, comprising administering to a patient in need thereof, an effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, where R¹ is a halogen; R² is C_1-6 haloalkyl; R³ is hydrogen or C_1-6 alkyl; R⁴ is hydrogen; n is 0 and A¹ is -CH- or -N-, A² is -CH- and A³ is -N-. Invention also relates to a pharmaceutical combination for treating pancreatic cancer, comprising a compound of Formula I and one or more additional therapeutic compounds selected from FOLFIRINOX or gemcitabine and paclitaxel.

.

EFFECT: effective method of treating pancreatic cancer based on the compound of Formula I.

11 cl, 2 dwg, 4 tbl, 3 ex