MODIFIED-RELEASE THERAPEUTIC SYSTEMS FOR ORAL ADMINISTRATION OF MENTHOL IN THE TREATMENT OF INTESTINAL DISORDERS Russian patent published in 2019 - IPC A61K31/45 A61K47/38 A61K47/00 A61K9/22 A61K9/32 A61P1/00 A61P29/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: disclosed is a colon-specific delayed-release pharmaceutical composition. Pharmaceutical composition comprises a) a monolithic matrix core comprising hydroxypropyl methylcellulose, wherein ground or micronised menthol is dispersed, wherein the mass ratio of menthol to hydroxypropyl methylcellulose is in the range from 1:5 to 4:1, and b) gastro-resistant core coating (a). Core can comprise only one hydroxypropyl methylcellulose, having an effective viscosity at 20 °C in 2 % aqueous solution in the range from 80 to 120 MPa·s or a mixture of at least two hydroxypropyl methylcelluloses with different effective viscosities. According to the invention, the composition is used for treating irritable bowel syndrome.

EFFECT: according to the invention, the pharmaceutical composition provides a menthol release profile for 24 hours.

13 cl, 5 ex