COMPOSITIONS AND METHODS FOR ENHANCING TOPICAL APPLICATION OF ACIDIC BENEFIT AGENT Russian patent published in 2019 - IPC A61K9/14 A61K31/191 A61K47/04 A61K47/10 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a powder for local administration of a biologically active agent to a human or animal. Said powder contains core/shell particles having an average size of less than 1,000 microns, containing: a liquid core without water containing a polar liquid having a percentage surface polarity of at least 24 %, containing at least 50 wt.% of glycerol, polyglycerol or a mixture thereof, from 0.001 to 20 wt.% of ibuprofen and from 0.1 to 20 wt.% of, at least, one alkaline solubility enhancing agent selected from sodium hydroxide, potassium hydroxide, ammonium hydroxide, calcium hydroxide, magnesium hydroxide, potassium carbonate, sodium carbonate, calcium carbonate, magnesium carbonate, ethylamine, diethylamine, triethylamine, diisopropylethylamine, ethanolamine, diethanolamine, triethanolamine, ethylene diamine, triisopropanolamine, and mixtures thereof; and a shell containing hydrophobic particles containing highly dispersed silica. Also disclosed is a method for topical administration of a biologically active agent to a human or animal that includes topical application of a powder composition on the skin.

EFFECT: group of inventions provides stable ibuprofen particles for topical application.

8 cl, 5 tbl, 4 ex