FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to taxane compounds having a structure represented by the following general formula I:
where R1 is benzoyl, tert-butyloxycarbonyl or N,N'-dimethylcarbamoyl; R2 is phenyl, 
or 
R3 is -OMe, -OOCOC3, -OCON (CH3)2 or -OCOSC2H5; R4 is -OMe, -OOCOC3, -OCON (CH3)2, -OCOSC2H5 or H, wherein R3 and R4 do not represent -OM simultaneously; or their pharmaceutically acceptable non-toxic salts or isomers. Also disclosed are taxane compounds of formula II, an anti-tumor pharmaceutical composition, use of taxane compounds and a composition, a method of producing taxane compounds.
EFFECT: disclosed taxane compounds have improved oral bioavailability and are characterized by strong cytotoxicity with respect to a number of human cancer cell lines and broad spectrum anti-tumor effects.
10 cl, 67 dwg, 23 ex, 6 tbl
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