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(19)

(11)

2 722 441

(13)

(51)

IPC

C07D209/18(2006-01-01)

C07D401/06(2006-01-01)

C07D403/12(2006-01-01)

C07D405/06(2006-01-01)

C07D409/06(2006-01-01)

A61K31/404(2006-01-01)

A61P35/00(2006-01-01)

A61P15/00(2006-01-01)

(21) (22)

Application

2018135203, 2017-03-24

(24)

Start date

2017-03-24

(22)

Actual filing date

2017-03-24

(45)

Published

2020-06-01

(72)

Inventor

Lu, TszyanyuDin, Charlz Z.Khu, LikhunKhe, KhuejtszyunChen, ShukhuejDun, TszyatsyanVan, Te-Lin

(73)

Holder

Losin Farmasyutikal Ko., Ltd.Shandun Losin Farmasyutikal Grup Stok Ko., Ltd.

SUBSTITUTED INDOLE COMPOUNDS AS REDUCING REGULATORS OF ESTROGEN RECEPTORS Russian patent published in 2020 - IPC C07D209/18 C07D401/06 C07D403/12 C07D405/06 C07D409/06 A61K31/404 A61P35/00 A61P15/00

Abstract RU 2722441 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to an indole compound of formula (I), where the values Y, Z, R₁-R₆, m, n are defined in the claim, its pharmaceutical composition and use as a decreasing regulator of estrogen receptors in preparing drugs for treating estrogen-receptor-positive breast cancer.

EFFECT: disclosed are substituted indole compounds as reducing regulators of estrogen receptors.

21 cl, 5 tbl, 65 ex

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RU 2 722 441 C2

Authors

Lu, Tszyanyu

Din, Charlz Z.

Khu, Likhun

Khe, Khuejtszyun

Chen, Shukhuej

Dun, Tszyatsyan

Van, Te-Lin

Dates

2020-06-01—Published

2017-03-24—Filed