BETA-LACTAMASE INHIBITORS Russian patent published in 2018 - IPC C07F5/02 A61K31/69 A61P31/04 

FIELD: biochemistry.

SUBSTANCE: invention relates to a boron-containing compound of formula (I) or a pharmaceutically acceptable salt or stereoisomer thereof: (I). In formula (I), L is a bond, -CR¹R²-, >C=O, or =CR¹-; M is a bond or -N (R⁴)-; m is 0 or 1; n is 0 or 1; with the proviso that when n is 0, then M is a bond; p equals 1 or 2; X¹ is -OH; Z is >C=O; CycA is cyclobutane, cyclopentane or cyclohexane; R^a, R^b and R^c represent a hydrogen atom; each R¹ and R² is independently selected from the group consisting of a hydrogen atom, C₁-C₆-alkyl and -NR⁴R⁵, R³ is hydrogen atom; R^d is selected from the group consisting of a hydrogen atom and C₁-C₆ alkyl; each R⁴ and R⁵ is independently selected from the group consisting of a hydrogen atom, C₁-C₆-alkyl, 3-6-membered cycloalkyl, 3-6-membered heterocyclyl, 5-6-membered heteroaryl, C₁-C₆ alkyl(3-6-membered cycloalkyl) and C₁-C₆ alkyl(5-6 membered heteroaryl); or R⁴ and R⁵, taken together, form a 3-6 membered heterocycle with a nitrogen atom, to which they are attached; each R⁶ and R⁷ is independently selected from the group consisting of a hydrogen atom, C₁-C₆ alkyl, -OH, -SR¹⁰, -NR⁴R⁵, -NR⁴C(O)OR⁵, -C(O)OR⁵ and -NR⁴SO₂R⁵; each R¹⁰ is independently C₁-C₆-alkyl; and each Y is independently selected from the group consisting of -OH, -NR⁴R⁵, -(CR⁶R⁷)_vNR⁴R⁵, -NR⁴(CR⁶R⁷)_vNR⁴R⁵, -N(R⁴)C(O)(CR⁶R⁷)_vNR⁴R⁵, -(CR⁶R⁷)_vN(R⁴)C(O)(CR⁶R⁷)_vNR⁴R⁵, -NR⁵C(O)NR⁴(CR⁶R⁷)_vNR⁴R⁵, -N(R⁴)C(=NR⁵)R⁶, -(CR⁶R⁷)_vN(R⁴)C(=NR⁵)NR⁴R⁵, -NR⁴(CR⁶R⁷)_vN(R⁴)C(=NR⁵)NR⁴R⁵, -NR⁴C(=NR⁵)NR⁴R⁵, -(CR⁶R⁷)_vNR⁴(CR⁶R⁷⁾_vNR⁴R⁵, -NR⁴(CR⁶R⁷)_vR₆, -NR⁴(CR⁶R⁷)_vNR⁴(CR⁶R⁷)_vNR⁴R⁵, -(3-6-membered heterocyclyl) NR⁴R⁵, -(3-6-membered heterocyclyl)N(R⁴)C(=NR⁵)NR⁴R⁵, -NR⁴(CR⁶R⁷)_v(5-6 membered heteroaryl), -NR⁴(CR⁶R⁷)_v-(3-6-membered heterocyclyl), -NR⁴(CR⁶R⁷)_vNR⁵-(5-6-membered heteroaryl) and -NR⁴(CR^6thR^7th)_v-(3-6-membered heterocyclyl)-C(=NR⁵)NR⁴R⁵; and v is 1, 2, or 3. Pharmaceutical composition and a method of treating a bacterial infection are also provided.

EFFECT: compound of formula (I) is used to treat a bacterial infection.

25 cl, 108 ex, 4 tbl, 38 outlines