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(19)

RU

(11)

2 779 477

(13)

C2

(51)

IPC

C07K5/10(2006-01-01)

A61K38/07(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2019126728, 2018-02-22

(24)

Start date

2018-02-22

(22)

Actual filing date

2018-02-22

(45)

Published

2022-09-07

(72)

Inventor

Smith, Peter, AndrewRoberts, Tucker, CurranHiguchi, Robert, I.Paraselli, PrasunaKoehler, Michael, F., T.Schwarz, Jacob, BradleyCrawford, James, JohnLy, Cuong Q.Hanan, Emily, J.Hu, HuiyongChen, YongshengYu, ZhiyongWinship, Paul Colin MichaelMccleod, CalumBlench, Toby

(73)

Holder

Rqx Pharmaceuticals, Inc.Genentech, Inc.

MACROCYCLIC WIDE-RANGE ANTIBIOTICS Russian patent published in 2022 - IPC C07K5/10 A61K38/07 A61P31/04 

Abstract RU 2779477 C2

FIELD: medicine.

SUBSTANCE: invention relates to antibacterial compounds of the formula V, where values of R1-R18, R27, R28, X, Y, Z, q, p are specified in the claims, which are characterized by a wide range of bioactivity. Compounds act by inhibition of bacterial signal peptidase type 1 (SpsB), vital protein in bacteria. Pharmaceutical compositions and methods for the treatment, using such compounds, are also provided.

EFFECT: obtaining macrocyclic wide-range antibiotics.

38 cl, 8 tbl, 449 ex

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RU 2 779 477 C2

Authors

Smith, Peter, Andrew

Roberts, Tucker, Curran

Higuchi, Robert, I.

Paraselli, Prasuna

Koehler, Michael, F., T.

Schwarz, Jacob, Bradley

Crawford, James, John

Ly, Cuong Q.

Hanan, Emily, J.

Hu, Huiyong

Chen, Yongsheng

Yu, Zhiyong

Winship, Paul Colin Michael

Mccleod, Calum

Blench, Toby

Dates

2022-09-07—Published

2018-02-22—Filed

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