STABLE COMBINED PHARMACEUTICAL COMPOSITION Russian patent published in 2019 - IPC A61K31/138 A61K31/4422 A61K9/20 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to medicine, specifically to a packaged pharmaceutical product comprising a stable solid pharmaceutical composition and a moisture-impermeable package, wherein said composition contains a homogeneous mixture of a base of amlodipine or amlodipine besylate and bisoprolol fumarate and pharmaceutically acceptable excipients, is packaged in said moisture-impermeable package and further contains less than 0.5 % of weight of active ingredients of compound of formula

and where said moisture-proof package is a blister pack of cold molding from composite foil OPA/AL/PVC (foil of oriented polyamide/aluminum/polyvinyl chloride), coated with aluminum membrane foil.

EFFECT: invention provides a packaged pharmaceutical product wherein the amount of impurities does not exceed ½ % during preparation or during storage until expiry of the composition for at least two years.

8 cl, 2 ex, 2 tbl