PHARMACEUTICAL COMPOSITION CONTAINING BETA-BLOCKER, CONVERTING ENZYME INHIBITOR AND HYPOTENSIVE AGENT OR NSAID Russian patent published in 2021 - IPC A61K9/48 A61K31/138 A61K31/404 A61K31/4422 A61K31/616 A61P9/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: first invention is a pharmaceutical composition in the form of a capsule for the treatment or prevention of cardiovascular diseases, consisting of bisoprolol, perindopril or their pharmaceutically acceptable salts and one of: amlodipine, indapamide or acetylsalicylic acid or their pharmaceutically acceptable salts; in combination with one or several pharmaceutically acceptable fillers, where bisoprolol or its pharmaceutically acceptable salts, perindopril or its pharmaceutically acceptable salts, amlodipine or its pharmaceutically acceptable salts and indapamide or its pharmaceutically acceptable salts are presented in the form of mini-granules, and aspirin or its pharmaceutically acceptable salts are in the form of a tablet coated with a shell resistant to the action of gastric juice, and perindopril is in the form of perindopril tert-butylamine or perindopril arginine. The second invention is the use of the specified composition for the treatment or prevention of cardiovascular diseases, preferably arterial hypertension and stable coronary heart disease.

EFFECT: group of inventions provides a solution to the problem of interaction of components of the combination in the composition of the dosage form, as well as an increase in patient compliance.

7 cl, 10 tbl, 8 ex