NOVEL 3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONES AND 2,3-DIHYDRO-ISOINDOLE-1-ONES Russian patent published in 2019 - IPC C07D401/14 C07D471/04 A61K31/4545 A61K31/4035 A61K31/437 A61P13/12 A61P9/04 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I), in which R¹, R² are independently selected from H and alkyl; R⁷ and R⁹ are independently selected from H and halogen; R⁸ and R¹¹ together form -CH₂-CH₂-; R¹⁰ is H or R¹⁰ and R¹¹ together form - (CH₂)_w-; A is -C(O)- or -S(O)₂-; B is -C- or -N-; R¹² is alkyl, cycloalkyl or substituted heteroaryl, where the substituted heteroaryl is a monovalent aromatic monocyclic ring system of 3-6 ring carbon atoms and 1 or 2 heteroatoms selected from N, where the substituted heteroaryl is substituted with one to three substitutes independently selected from H, alkyl and halogen; R¹³ is halogen, cyano or alkoxy; R¹⁴ is H; m and n are 0; p is from 0 and 1; w is 1, 2 or 3; and to their pharmaceutically acceptable salts. Invention also relates to a pharmaceutical composition inhibiting aldosterone synthase based on said compounds.

(I).

EFFECT: obtaining novel compounds and pharmaceutical compositions based thereon, which can be used in medicine for treating chronic renal disease, congestive heart failure, hypertension.

23 cl, 2 tbl, 49 ex