DUOCARMICIN ADC SHOWING IMPROVED ANTI-TUMOUR ACTIVITY IN VIVO Russian patent published in 2019 - IPC A61K47/68 A61K47/65 A61P35/00 

Abstract RU 2689779 C2

FIELD: medicine; chemistry.

SUBSTANCE: invention relates to use of duocarmicin conjugates of antibody-drug (ADC) of formula (II) for treating human solid tumours expressing HER2, wherein said human solid tumour expressing HER2 is HER2 IHC 2+ or 1.

EFFECT: advantage of conjugates of the declared invention consists in possibility of their application for treatment of thrice negative breast cancer (TNBC).

8 cl, 12 dwg, 1 ex

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RU 2 689 779 C2

Authors

Dokter Villem

Besker Patrik Khenri

Gudings Peter Jokhannes

Verkhejden Gejsbertus Fransiskus Mariya

Dates

2019-05-29Published

2015-01-09Filed