COMBINATIONS OF ANTI-HER2-ANTIBODY-DRUG CONJUGATE AND CHEMOTHERAPEUTIC REMEDIES, AND APPLICATION METHODS Russian patent published in 2022 - IPC A61K39/395 A61K31/337 A61K47/68 A61K45/06 A61P35/00 

Abstract RU 2781195 C2

FIELD: medicine.

SUBSTANCE: invention relates to a method for the treatment of malignant tumor expressing ErbB2, including the administration of a therapeutic combination, in the form of a combined composition or alternately, to a mammal, where the therapeutic combination contains trastuzumab-MCC-DM1 and docetaxel, where the administration of the therapeutic combination leads to an additive effect compared to the administration of trastuzumab-MCC-DM1 or docetaxel in the form of separate remedies, where the amount of trastuzumab-MCC-DM1 is from 0.3 to 15 mg/kg, and where the amount of docetaxel is about 30 mg/kg.

EFFECT: obtaining combination of an antibody-drug conjugate and chemotherapeutic means.

10 cl, 37 dwg, 21 tbl, 5 ex

Similar patents RU2781195C2

Title Year Author Number
COMBINATIONS OF ANTIBODY DRUG CONJUGATES AND CHEMOTHERAPEUTIC COMPOUNDS AND METHODS FOR USING 2009
  • Berri Linn
  • Fillips Gejl L'Juis
  • Slivkovski Mark Ks.
RU2510272C2
COMBINATIONS OF ANTI-HER2 ANTIBODY-DRUG CONJUGATE AND CHEMOTHERAPEUTIC AGENTS AND METHODS OF USE 2013
  • Berri Linn
  • Fillips Gejl Lyuis
  • Slivkovski Mark Ks.
RU2671489C2
MUTANT SELECTIVITY AND COMBINATIONS OF A PHOSPHOINOSITIDE-3-KINASE INHIBITOR COMPOUND AND CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER 2013
  • Belvin Marsiya
  • Fridman Lori
  • Sampat Dipak
  • Vallin Dzheffri
RU2665949C2
COMBINATIONS OF INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE AND CHEMIOTHERAPEUTIC AGENTS AND METHODS OF APPLICATION 2008
  • Belvin Marsija
  • Fridman Lori
  • Kheflikh Klaus
  • Sampat Dipak
  • Vidzhapurkar Ulka
  • Vallin Dzheffri
  • Dzhonson Lejza
  • Singkh Mallika
  • Patel' Sonal'
RU2523890C2
METHODS OF TREATING EARLY BREAST CANCER WITH TRASTUZUMAB-MCC-DM1 AND PERTUZUMAB 2015
  • Green, Marjorie, C.
  • Guardino, Alice, Elizabeth
RU2725093C2
ANTIBODY-DRUG CONJUGATES (ADC) WITH DUOCARMICIN USED FOR TREATING ENDOMETRIAL CANCER 2015
  • Santin Allesandro Devid
  • Gudings Peter Jokhannes
RU2686085C2
DUOCARMICIN ADC SHOWING IMPROVED ANTI-TUMOUR ACTIVITY IN VIVO 2015
  • Dokter Villem
  • Besker Patrik Khenri
  • Gudings Peter Jokhannes
  • Verkhejden Gejsbertus Fransiskus Mariya
RU2689779C2
DUOCARMYCIN ADCs EXHIBITING IMPROVED ANTI-TUMOUR ACTIVITY IN VIVO 2015
  • Dokter, Villem
  • Gudings, Peter Jokhannes
  • Verkhejden, Gejsbertus Fransiskus Mariya
  • Besker, Patrik Khenri
RU2769700C2
TREATING SYD985 PATIENTS WITH T-DM1 REFRACTORY CANCER 2016
  • Vortman, Gerrit
  • Koper, Norbert Peter
RU2728101C2
TARGETED EXPOSURE TO TRASTUZUMAB-RESISTANT HER2+ BREAST CANCER BY HER3-TARGETED NANOPARTICLES 2015
  • Medina-Kauve Lali K.
  • Sims Dzhessika
  • Taguejm Majkl
  • Khenson Kris
  • Tsuj Syaotszyan
RU2692104C2

RU 2 781 195 C2

Authors

Berry, Leanne

Phillips, Gail, Lewis

Sliwkowski, Mark, X.

Dates

2022-10-07Published

2018-10-12Filed