NOVEL COMPOUNDS Russian patent published in 2019 - IPC C07D403/12 C07D401/12 C07D413/12 C07D417/12 C07D417/14 A61K31/4709 A61P25/00 A61P29/00 A61P31/12 A61P31/04 A61P3/00 A61P35/00 

Abstract RU 2691389 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds of formula (I), where R1-R8 such as defined herein, or pharmaceutically acceptable salts thereof, as inhibitors of ubiquitin-C-terminal hydrolase L1 (UCHL1).

EFFECT: present invention also relates to use of compounds for treating cancer, which is associated with UCHL1 activity and other conditions associated with UCHL1.

18 cl, 2 dwg, 15 tbl, 266 ex

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RU 2 691 389 C2

Authors

Dzhons Elison

Kemp Mark Ien

Stokli Martin Li

Gibson Karl Richard

Uitlok Gevin Alister

Medin Endryu

Dates

2019-06-13Published

2015-09-22Filed