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(19)

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2 811 601

(13)

(51)

IPC

C07D401/04(2006-01-01)

C07D401/14(2006-01-01)

C07D405/14(2006-01-01)

C07D409/14(2006-01-01)

C07D413/14(2006-01-01)

C07D417/14(2006-01-01)

C07D471/04(2006-01-01)

C07D491/107(2006-01-01)

A61K31/454(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2019108306, 2019-03-22

(24)

Start date

2015-02-06

(22)

Actual filing date

2019-03-22

(45)

Published

2024-01-15

(72)

Inventor

Brown Giles AlbertCansfield Julie ElaineCongreve Miles StuartO'Brien Michael AlistairPickworth MarkRackham Mark DavidTehan Benjamin GeraldTeobold Barry John

(73)

Holder

Heptares Therapeutics Limited

BICYCLIC NITROGEN-CONTAINING COMPOUNDS AS AGONISTS OF M1 MUSCARINIC RECEPTORS Russian patent published in 2024 - IPC C07D401/04 C07D401/14 C07D405/14 C07D409/14 C07D413/14 C07D417/14 C07D471/04 C07D491/107 A61K31/454 A61P25/00

Abstract RU 2811601 C1

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to new compounds of formula (1b)

or a pharmaceutically acceptable salt thereof, wherein Q is selected from the specific structures presented, R³ is hydrogen; R⁴ represents either hydrogen or methyl; and the dotted line indicating an optional second carbon-carbon bond is absent, as well as to pharmaceutical compositions based thereon.

EFFECT: new compounds have been obtained that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are suitable for the treatment of diseases mediated by muscarinic M1/M4 receptors.

31 cl, 4 tbl, 2 dwg

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RU 2 811 601 C1

Authors

Brown Giles Albert

Cansfield Julie Elaine

Congreve Miles Stuart

O'Brien Michael Alistair

Pickworth Mark

Rackham Mark David

Tehan Benjamin Gerald

Teobold Barry John

Dates

2024-01-15—Published

2019-03-22—Filed